Motif ID: TFAP2{A,C}.p2

Z-value: 3.601


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_10527772-0.282.9e-01Click!
TFAP2Cchr20_+_54637714-0.165.4e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_39573363 6.757 NM_002220
 ITPKA
inositol 1,4,5-trisphosphate 3-kinase A
chr3_-_130807865 5.874 NM_015103
 PLXND1
plexin D1
chr15_+_64782468 4.904 SMAD6
SMAD family member 6
chr19_-_11452439 4.841 NM_001420
NM_032281
 ELAVL3

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

chr15_-_81113676 4.830 NM_030594
 CPEB1
cytoplasmic polyadenylation element binding protein 1
chr4_+_2031036 4.808 NM_178557
 NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr12_+_109956210 4.480 NM_015267
 CUX2
cut-like homeobox 2
chr3_-_129689394 4.334 NM_001145662
 GATA2
GATA binding protein 2
chr19_+_540849 4.229 NM_001194
 HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr16_-_87535106 4.224 NM_175931
 CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr9_+_125813849 4.213 LHX2
LIM homeobox 2
chr9_+_94987032 4.129 NM_006648
 WNK2
WNK lysine deficient protein kinase 2
chr1_+_1557419 3.941 NM_006983
 MMP23B
matrix metallopeptidase 23B
chr12_+_2032649 3.846 NM_000719
NM_001129827
NM_001129829
NM_001129830
NM_001129831
NM_001129832
NM_001129833
NM_001129834
NM_001129835
NM_001129836
NM_001129837
NM_001129838
NM_001129839
NM_001129840
NM_001129841
NM_001129842
NM_001129843
NM_001129844
NM_001129846
NM_001167623
NM_001167624
NM_001167625
NM_199460
 CACNA1C






















calcium channel, voltage-dependent, L type, alpha 1C subunit






















chr5_+_170668892 3.751 NM_021025
 TLX3
T-cell leukemia homeobox 3
chr2_+_120820140 3.711 NM_002193
 INHBB
inhibin, beta B
chr8_-_144583718 3.582 NM_201589
 MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr2_+_42128521 3.485 NM_138370
 PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr1_-_11674264 3.484 NM_001127325
 MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chrX_+_68641802 3.422 NM_015686
 FAM155B
family with sequence similarity 155, member B

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 105 entries
enrichment   p-value GO term description
1.86 1.13e-02 GO:0030177 positive regulation of Wnt receptor signaling pathway
1.56 5.29e-04 GO:0030111 regulation of Wnt receptor signaling pathway
1.44 1.35e-04 GO:0051129 negative regulation of cellular component organization
1.42 6.21e-04 GO:0048568 embryonic organ development
1.38 9.95e-03 GO:0002009 morphogenesis of an epithelium
1.38 3.65e-02 GO:0045664 regulation of neuron differentiation
1.37 6.08e-08 GO:0000904 cell morphogenesis involved in differentiation
1.37 5.64e-05 GO:0051301 cell division
1.36 1.92e-02 GO:0003002 regionalization
1.35 9.85e-04 GO:0007411 axon guidance
1.34 1.87e-06 GO:0007417 central nervous system development
1.34 1.94e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.34 9.27e-03 GO:0001944 vasculature development
1.33 4.19e-09 GO:0030182 neuron differentiation
1.33 5.92e-08 GO:0032989 cellular component morphogenesis
1.33 2.22e-07 GO:0000902 cell morphogenesis
1.33 8.22e-05 GO:0048812 neuron projection morphogenesis
1.33 1.22e-04 GO:0007409 axonogenesis
1.33 8.51e-03 GO:0051325 interphase
1.32 2.93e-11 GO:0022008 neurogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
1.43 8.46e-04 GO:0031252 cell leading edge
1.16 1.31e-02 GO:0005794 Golgi apparatus
1.14 2.64e-05 GO:0044428 nuclear part
1.13 1.33e-04 GO:0005829 cytosol
1.13 6.75e-03 GO:0012505 endomembrane system
1.12 1.71e-03 GO:0070013 intracellular organelle lumen
1.12 3.62e-03 GO:0031981 nuclear lumen
1.11 4.34e-03 GO:0031090 organelle membrane
1.11 4.76e-03 GO:0043233 organelle lumen
1.11 6.56e-03 GO:0031974 membrane-enclosed lumen
1.10 4.55e-23 GO:0005737 cytoplasm
1.10 7.18e-12 GO:0044444 cytoplasmic part
1.10 1.46e-03 GO:0043234 protein complex
1.10 6.91e-03 GO:0043228 non-membrane-bounded organelle
1.10 6.91e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.09 2.19e-17 GO:0043227 membrane-bounded organelle
1.09 4.10e-17 GO:0043231 intracellular membrane-bounded organelle
1.09 5.59e-08 GO:0005634 nucleus
1.08 7.42e-27 GO:0044424 intracellular part
1.08 2.27e-26 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
1.33 5.02e-06 GO:0019904 protein domain specific binding
1.28 3.04e-02 GO:0016563 transcription activator activity
1.20 5.64e-03 GO:0019899 enzyme binding
1.19 1.16e-03 GO:0001071 nucleic acid binding transcription factor activity
1.19 1.16e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.19 4.27e-02 GO:0043565 sequence-specific DNA binding
1.18 1.28e-03 GO:0030528 transcription regulator activity
1.13 1.33e-27 GO:0005515 protein binding
1.13 1.14e-03 GO:0017076 purine nucleotide binding
1.13 1.30e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.13 1.30e-03 GO:0032553 ribonucleotide binding
1.13 1.30e-03 GO:0032555 purine ribonucleotide binding
1.12 5.22e-04 GO:0000166 nucleotide binding
1.12 3.16e-02 GO:0016740 transferase activity
1.08 1.29e-04 GO:0003824 catalytic activity
1.06 4.45e-14 GO:0005488 binding